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VERTEX PHARMACEUTICALS INC (VRTX) Stock Fundamental Analysis

USA - Nasdaq - NASDAQ:VRTX - US92532F1003 - Common Stock

459.61 USD
-0.7 (-0.15%)
Last: 12/23/2025, 10:10:05 AM
Fundamental Rating

6

Overall VRTX gets a fundamental rating of 6 out of 10. We evaluated VRTX against 530 industry peers in the Biotechnology industry. While VRTX has a great profitability rating, there are some minor concerns on its financial health. VRTX has both an excellent growth and valuation score. This means it is growing and it is still cheap. This is a rare combination! These ratings would make VRTX suitable for value and growth investing!


Dividend Valuation Growth Profitability Health

7

1. Profitability

1.1 Basic Checks

In the past year VRTX was profitable.
In the past year VRTX had a positive cash flow from operations.
Of the past 5 years VRTX 4 years were profitable.
VRTX had a positive operating cash flow in 4 of the past 5 years.
VRTX Yearly Net Income VS EBIT VS OCF VS FCFVRTX Yearly Net Income VS EBIT VS OCF VS FCFYearly Net Income VS EBIT VS OCF VS FCF 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 0 1B 2B 3B 4B

1.2 Ratios

VRTX has a Return On Assets of 14.78%. This is amongst the best in the industry. VRTX outperforms 95.47% of its industry peers.
With an excellent Return On Equity value of 21.22%, VRTX belongs to the best of the industry, outperforming 96.42% of the companies in the same industry.
The Return On Invested Capital of VRTX (17.58%) is better than 97.17% of its industry peers.
VRTX had an Average Return On Invested Capital over the past 3 years of 19.67%. This is in line with the industry average of 18.22%.
Industry RankSector Rank
ROA 14.78%
ROE 21.22%
ROIC 17.58%
ROA(3y)10.62%
ROA(5y)14.47%
ROE(3y)13.73%
ROE(5y)19.12%
ROIC(3y)19.67%
ROIC(5y)20.26%
VRTX Yearly ROA, ROE, ROICVRTX Yearly ROA, ROE, ROICYearly ROA, ROE, ROIC 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 0 20 -20 40 -40

1.3 Margins

VRTX has a better Profit Margin (31.35%) than 96.04% of its industry peers.
VRTX has a better Operating Margin (38.70%) than 97.92% of its industry peers.
In the last couple of years the Operating Margin of VRTX has grown nicely.
VRTX's Gross Margin of 86.28% is amongst the best of the industry. VRTX outperforms 89.06% of its industry peers.
VRTX's Gross Margin has been stable in the last couple of years.
Industry RankSector Rank
OM 38.7%
PM (TTM) 31.35%
GM 86.28%
OM growth 3Y2.79%
OM growth 5Y6.75%
PM growth 3YN/A
PM growth 5YN/A
GM growth 3Y-0.74%
GM growth 5Y-0.17%
VRTX Yearly Profit, Operating, Gross MarginsVRTX Yearly Profit, Operating, Gross MarginsYearly Profit, Operating, Gross Margins 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 0 50 -50

6

2. Health

2.1 Basic Checks

The Return on Invested Capital (ROIC) is well above the Cost of Capital (WACC), so VRTX is creating value.
The number of shares outstanding for VRTX has been reduced compared to 1 year ago.
The number of shares outstanding for VRTX has been reduced compared to 5 years ago.
Compared to 1 year ago, VRTX has an improved debt to assets ratio.
VRTX Yearly Shares OutstandingVRTX Yearly Shares OutstandingYearly Shares Outstanding 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 50M 100M 150M 200M 250M
VRTX Yearly Total Debt VS Total AssetsVRTX Yearly Total Debt VS Total AssetsYearly Total Debt VS Total Assets 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 5B 10B 15B 20B

2.2 Solvency

There is no outstanding debt for VRTX. This means it has a Debt/Equity and Debt/FCF ratio of 0 and it is amongst the best of the sector and industry.
Industry RankSector Rank
Debt/Equity 0
Debt/FCF 0
Altman-Z N/A
ROIC/WACC2
WACC8.81%
VRTX Yearly LT Debt VS Equity VS FCFVRTX Yearly LT Debt VS Equity VS FCFYearly LT Debt VS Equity VS FCF 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 0 5B 10B 15B

2.3 Liquidity

A Current Ratio of 2.36 indicates that VRTX has no problem at all paying its short term obligations.
The Current ratio of VRTX (2.36) is worse than 72.08% of its industry peers.
A Quick Ratio of 2.00 indicates that VRTX should not have too much problems paying its short term obligations.
VRTX has a Quick ratio of 2.00. This is in the lower half of the industry: VRTX underperforms 74.91% of its industry peers.
Industry RankSector Rank
Current Ratio 2.36
Quick Ratio 2
VRTX Yearly Current Assets VS Current LiabilitesVRTX Yearly Current Assets VS Current LiabilitesYearly Current Assets VS Current Liabilites 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 5B 10B

7

3. Growth

3.1 Past

VRTX shows a strong growth in Earnings Per Share. In the last year, the EPS has been growing by 3303.92%, which is quite impressive.
VRTX shows a very negative growth in Earnings Per Share. Measured over the last years, the EPS has been decreasing by -44.14% yearly.
The Revenue has grown by 10.33% in the past year. This is quite good.
The Revenue has been growing by 21.50% on average over the past years. This is a very strong growth!
EPS 1Y (TTM)3303.92%
EPS 3Y-71.86%
EPS 5Y-44.14%
EPS Q2Q%9.59%
Revenue 1Y (TTM)10.33%
Revenue growth 3Y13.31%
Revenue growth 5Y21.5%
Sales Q2Q%10.99%

3.2 Future

VRTX is expected to show a strong growth in Earnings Per Share. In the coming years, the EPS will grow by 150.35% yearly.
Based on estimates for the next years, VRTX will show a quite strong growth in Revenue. The Revenue will grow by 9.70% on average per year.
EPS Next Y6342.88%
EPS Next 2Y738.5%
EPS Next 3Y328.69%
EPS Next 5Y150.35%
Revenue Next Year10.14%
Revenue Next 2Y9.44%
Revenue Next 3Y9.38%
Revenue Next 5Y9.7%

3.3 Evolution

The EPS growth rate is accelerating: in the next years the growth will be better than in the last years.
When comparing the Revenue growth rate of the last years to the growth rate of the upcoming years, we see that the growth is decreasing.
VRTX Yearly Revenue VS EstimatesVRTX Yearly Revenue VS EstimatesYearly Revenue VS Estimates 2014 2016 2018 2020 2022 2024 2026 2028 2030 2032 5B 10B 15B 20B
VRTX Yearly EPS VS EstimatesVRTX Yearly EPS VS EstimatesYearly EPS VS Estimates 2014 2016 2018 2020 2022 2024 2026 2028 2030 2032 0 10 20 30

7

4. Valuation

4.1 Price/Earnings Ratio

The Price/Earnings ratio is 26.48, which means the current valuation is very expensive for VRTX.
VRTX's Price/Earnings ratio is rather cheap when compared to the industry. VRTX is cheaper than 93.21% of the companies in the same industry.
VRTX is valuated at similar levels of the S&P average when we compare the Price/Earnings ratio to 26.61, which is the current average of the S&P500 Index.
Based on the Price/Forward Earnings ratio of 22.54, the valuation of VRTX can be described as rather expensive.
93.40% of the companies in the same industry are more expensive than VRTX, based on the Price/Forward Earnings ratio.
When comparing the Price/Forward Earnings ratio of VRTX to the average of the S&P500 Index (24.01), we can say VRTX is valued inline with the index average.
Industry RankSector Rank
PE 26.48
Fwd PE 22.54
VRTX Price Earnings VS Forward Price EarningsVRTX Price Earnings VS Forward Price Earnings ChartPrice Earnings - Forward Price Earnings PE FPE 20 40 60

4.2 Price Multiples

Based on the Enterprise Value to EBITDA ratio, VRTX is valued cheaper than 93.58% of the companies in the same industry.
Compared to the rest of the industry, the Price/Free Cash Flow ratio of VRTX indicates a rather cheap valuation: VRTX is cheaper than 93.40% of the companies listed in the same industry.
Industry RankSector Rank
P/FCF 34.94
EV/EBITDA 23.33
VRTX Per share dataVRTX EPS, Sales, OCF, FCF, BookValue per sharePer Share Data Per Share 20 40 60

4.3 Compensation for Growth

VRTX's low PEG Ratio(NY), which compensates the Price/Earnings for growth, indicates a rather cheap valuation of the company.
VRTX has a very decent profitability rating, which may justify a higher PE ratio.
A more expensive valuation may be justified as VRTX's earnings are expected to grow with 328.69% in the coming years.
PEG (NY)0
PEG (5Y)N/A
EPS Next 2Y738.5%
EPS Next 3Y328.69%

0

5. Dividend

5.1 Amount

No dividends for VRTX!.
Industry RankSector Rank
Dividend Yield 0%

VERTEX PHARMACEUTICALS INC

NASDAQ:VRTX (12/23/2025, 10:10:05 AM)

459.61

-0.7 (-0.15%)

Chartmill FA Rating
GICS SectorHealth Care
GICS IndustryGroupPharmaceuticals, Biotechnology & Life Sciences
GICS IndustryBiotechnology
Earnings (Last)11-03 2025-11-03/amc
Earnings (Next)02-09 2026-02-09/amc
Inst Owners97.5%
Inst Owner Change-2.14%
Ins Owners0.13%
Ins Owner Change-3.43%
Market Cap116.61B
Revenue(TTM)11.72B
Net Income(TTM)3.68B
Analysts76.41
Price Target496.99 (8.13%)
Short Float %1.76%
Short Ratio3.26
Dividend
Industry RankSector Rank
Dividend Yield 0%
Yearly DividendN/A
Dividend Growth(5Y)N/A
DPN/A
Div Incr Years0
Div Non Decr Years0
Ex-DateN/A
Surprises & Revisions
EPS beat(2)2
Avg EPS beat(2)3.29%
Min EPS beat(2)3.12%
Max EPS beat(2)3.45%
EPS beat(4)2
Avg EPS beat(4)-0.92%
Min EPS beat(4)-7.2%
Max EPS beat(4)3.45%
EPS beat(8)5
Avg EPS beat(8)-64.05%
EPS beat(12)7
Avg EPS beat(12)-42.39%
EPS beat(16)10
Avg EPS beat(16)-31.28%
Revenue beat(2)1
Avg Revenue beat(2)-0.58%
Min Revenue beat(2)-1.21%
Max Revenue beat(2)0.06%
Revenue beat(4)2
Avg Revenue beat(4)-0.82%
Min Revenue beat(4)-4.8%
Max Revenue beat(4)2.68%
Revenue beat(8)3
Avg Revenue beat(8)-0.69%
Revenue beat(12)4
Avg Revenue beat(12)-0.78%
Revenue beat(16)7
Avg Revenue beat(16)-0.32%
PT rev (1m)1.04%
PT rev (3m)1.36%
EPS NQ rev (1m)0.56%
EPS NQ rev (3m)2.37%
EPS NY rev (1m)1.66%
EPS NY rev (3m)1.36%
Revenue NQ rev (1m)0.25%
Revenue NQ rev (3m)-0.83%
Revenue NY rev (1m)0.05%
Revenue NY rev (3m)0.1%
Valuation
Industry RankSector Rank
PE 26.48
Fwd PE 22.54
P/S 9.95
P/FCF 34.94
P/OCF 31.36
P/B 6.73
P/tB 7.38
EV/EBITDA 23.33
EPS(TTM)17.36
EY3.78%
EPS(NY)20.39
Fwd EY4.44%
FCF(TTM)13.15
FCFY2.86%
OCF(TTM)14.65
OCFY3.19%
SpS46.21
BVpS68.26
TBVpS62.28
PEG (NY)0
PEG (5Y)N/A
Graham Number163.29
Profitability
Industry RankSector Rank
ROA 14.78%
ROE 21.22%
ROCE 22.25%
ROIC 17.58%
ROICexc 25.42%
ROICexgc 28.48%
OM 38.7%
PM (TTM) 31.35%
GM 86.28%
FCFM 28.47%
ROA(3y)10.62%
ROA(5y)14.47%
ROE(3y)13.73%
ROE(5y)19.12%
ROIC(3y)19.67%
ROIC(5y)20.26%
ROICexc(3y)48.65%
ROICexc(5y)54.9%
ROICexgc(3y)69.59%
ROICexgc(5y)85.25%
ROCE(3y)24.89%
ROCE(5y)25.65%
ROICexgc growth 3Y-29.98%
ROICexgc growth 5Y-9.76%
ROICexc growth 3Y-22.64%
ROICexc growth 5Y-1.94%
OM growth 3Y2.79%
OM growth 5Y6.75%
PM growth 3YN/A
PM growth 5YN/A
GM growth 3Y-0.74%
GM growth 5Y-0.17%
F-Score7
Asset Turnover0.47
Health
Industry RankSector Rank
Debt/Equity 0
Debt/FCF 0
Debt/EBITDA 0
Cap/Depr 189.83%
Cap/Sales 3.25%
Interest Coverage 374.91
Cash Conversion 78.49%
Profit Quality 90.81%
Current Ratio 2.36
Quick Ratio 2
Altman-Z N/A
F-Score7
WACC8.81%
ROIC/WACC2
Cap/Depr(3y)171.61%
Cap/Depr(5y)187.83%
Cap/Sales(3y)3.11%
Cap/Sales(5y)3.32%
Profit Quality(3y)N/A
Profit Quality(5y)N/A
High Growth Momentum
Growth
EPS 1Y (TTM)3303.92%
EPS 3Y-71.86%
EPS 5Y-44.14%
EPS Q2Q%9.59%
EPS Next Y6342.88%
EPS Next 2Y738.5%
EPS Next 3Y328.69%
EPS Next 5Y150.35%
Revenue 1Y (TTM)10.33%
Revenue growth 3Y13.31%
Revenue growth 5Y21.5%
Sales Q2Q%10.99%
Revenue Next Year10.14%
Revenue Next 2Y9.44%
Revenue Next 3Y9.38%
Revenue Next 5Y9.7%
EBIT growth 1Y5.79%
EBIT growth 3Y16.47%
EBIT growth 5Y29.7%
EBIT Next Year811.13%
EBIT Next 3Y127.98%
EBIT Next 5Y68.84%
FCF growth 1Y-20.64%
FCF growth 3YN/A
FCF growth 5YN/A
OCF growth 1Y-15.14%
OCF growth 3YN/A
OCF growth 5YN/A

VERTEX PHARMACEUTICALS INC / VRTX FAQ

What is the fundamental rating for VRTX stock?

ChartMill assigns a fundamental rating of 6 / 10 to VRTX.


Can you provide the valuation status for VERTEX PHARMACEUTICALS INC?

ChartMill assigns a valuation rating of 7 / 10 to VERTEX PHARMACEUTICALS INC (VRTX). This can be considered as Undervalued.


What is the profitability of VRTX stock?

VERTEX PHARMACEUTICALS INC (VRTX) has a profitability rating of 7 / 10.


What is the expected EPS growth for VERTEX PHARMACEUTICALS INC (VRTX) stock?

The Earnings per Share (EPS) of VERTEX PHARMACEUTICALS INC (VRTX) is expected to grow by 6342.88% in the next year.