| Dec 11, 2025 | RA Capital Nexus Fund III, L.P. | Other Disposition | 20440000 | 0.00 | $ 0.00 |
| Dec 11, 2025 | Kolchinsky Peter | Other Disposition | 20440000 | 0.00 | $ 0.00 |
| Dec 11, 2025 | Shah Rajeev M. | Other Disposition | 20440000 | 0.00 | $ 0.00 |
| Dec 11, 2025 | RA CAPITAL MANAGEMENT, LLC | Open Market Purchase | 314561 | 2.40 | $ 754,737.14 |
| Dec 11, 2025 | RA Capital Healthcare Fund LP | Open Market Purchase | 314561 | 2.40 | $ 754,737.14 |
| Dec 11, 2025 | RA Capital Nexus Fund, L.P. | Open Market Purchase | 314561 | 2.40 | $ 754,737.14 |
| Dec 11, 2025 | RA Capital Nexus Fund II, L.P. | Open Market Purchase | 314561 | 2.40 | $ 754,737.14 |
| Dec 11, 2025 | RA Capital Nexus Fund III, L.P. | Open Market Purchase | 314561 | 2.40 | $ 754,737.14 |
| Dec 11, 2025 | Kolchinsky Peter | Open Market Purchase | 314561 | 2.40 | $ 754,737.14 |
| Dec 11, 2025 | Shah Rajeev M. | Open Market Purchase | 314561 | 2.40 | $ 754,737.14 |
| Dec 11, 2025 | RA CAPITAL MANAGEMENT, LLC | Other Disposition | 20440000 | 0.00 | $ 0.00 |
| Dec 11, 2025 | RA Capital Healthcare Fund LP | Other Disposition | 20440000 | 0.00 | $ 0.00 |
| Dec 11, 2025 | RA Capital Nexus Fund, L.P. | Other Disposition | 20440000 | 0.00 | $ 0.00 |
| Dec 11, 2025 | RA Capital Nexus Fund II, L.P. | Other Disposition | 20440000 | 0.00 | $ 0.00 |
| Aug 7, 2025 | Thomas Stephen Basil | Grant | 100375 | 0.00 | $ 0.00 |
| Jun 30, 2025 | Brennan Aoife | Open Market Sale | 20618 | 1.22 | $ 25,153.96 |
| Jun 27, 2025 | Brennan Aoife | Option Excercise | 68750 | | $ 0.00 |
| Jun 27, 2025 | Thomas Stephen Basil | Option Excercise | 25094 | | $ 0.00 |
| Jun 20, 2025 | Pimblett Emily | Open Market Sale | 1242 | 1.24 | $ 1,540.08 |
| Jun 18, 2025 | Pimblett Emily | Option Excercise | 5000 | | $ 0.00 |
| Mar 27, 2025 | Thomas Stephen Basil | Option Excercise | 25093 | | $ 0.00 |
| Mar 20, 2025 | Pimblett Emily | Open Market Sale | 1199 | 1.31 | $ 1,570.69 |
| Mar 18, 2025 | Pimblett Emily | Option Excercise | 5000 | | $ 0.00 |
| Jan 1, 2025 | Thomas Stephen Basil | Option Excercise | 50188 | | $ 0.00 |
| Dec 19, 2024 | Pimblett Emily | Open Market Sale | 1235 | 2.02 | $ 2,494.70 |